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lüll Interactions of HIV-1 with antigen-presenting cells Hewson T; Lone N; Moore M; Howie SImmunol Cell Biol 1999[Aug]; 77 (4): 289-303There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.|Antigen-Presenting Cells/*immunology/virology[MESH]|Apoptosis[MESH]|CD4-Positive T-Lymphocytes/immunology/virology[MESH]|Cytokines/biosynthesis[MESH]|HIV Antigens[MESH]|HIV Envelope Protein gp120/immunology[MESH]|HIV Infections/etiology/immunology/virology[MESH]|HIV-1/genetics/*immunology/*pathogenicity[MESH]|HLA Antigens/genetics[MESH]|Humans[MESH]|Membrane Fusion[MESH]|Polymorphism, Genetic[MESH]|Receptors, HIV/genetics[MESH]|Signal Transduction[MESH]|T-Lymphocytes, Helper-Inducer/classification/immunology[MESH]|Virus Replication[MESH] |