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lüll Do self-perpetuating B lymphocytes drive human autoimmune disease?Edwards JC; Cambridge G; Abrahams VMImmunology 1999[Jun]; 97 (2): 188-96Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are indications that T-lymphocyte control has been subverted by self-perpetuating B lymphocytes. Potential mechanisms in other autoimmune states are less clear, but a number of observations suggest that misappropriation of immunological memory by B lymphocytes may be a common feature of human autoantibody-associated disease. Put simply, autoantibodies drive their own production. If so, the availability of safe B-lymphocyte-depleting agents provides a potential means for reversal of autoimmunity.|Arthritis, Rheumatoid/immunology[MESH]|Autoantibodies/biosynthesis[MESH]|Autoimmune Diseases/*immunology[MESH]|B-Lymphocytes/*immunology[MESH]|Humans[MESH]|Immunologic Memory[MESH]|Rheumatoid Factor/immunology[MESH] |