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lüll Cell-based and animal models for hepatitis B and C viruses Schinazi RF; Ilan E; Black PL; Yao X; Dagan SAntivir Chem Chemother 1999[May]; 10 (3): 99-114Reliable cell-based assays and animal models have been developed for evaluating agents against hepatitis B virus. Although much progress has been made, in vitro and in vivo assays for hepatitis C virus are still on the horizon. Advances towards establishing inexpensive and reliable experimental models have accelerated the development of therapeutic modalities for these life-threatening viral infections. The characterization of well-defined viral targets coupled with improved molecular diagnostic technologies have illuminated this field.|*Disease Models, Animal[MESH]|Animals[MESH]|Antiviral Agents/pharmacology[MESH]|Cells, Cultured[MESH]|Drug Evaluation, Preclinical/methods[MESH]|Hepacivirus/*drug effects/genetics[MESH]|Hepatitis B virus/*drug effects/genetics[MESH]|Hepatitis B/*drug therapy/virology[MESH]|Hepatitis C/*drug therapy/virology[MESH]|Humans[MESH]|Microbial Sensitivity Tests[MESH] |