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lüll Visual performance in giant cell arteritis (temporal arteritis) after 1 year of therapy Kupersmith MJ; Langer R; Mitnick H; Spiera R; Spiera H; Richmond M; Paget SBr J Ophthalmol 1999[Jul]; 83 (7): 796-801AIMS: To determine if patients with giant cell arteritis (GCA) treated with corticosteroids develop delayed visual loss or drug related ocular complications. METHODS: In a multicentre prospective study patients with GCA (using precise diagnostic criteria) had ophthalmic evaluations at predetermined intervals up to 1 year. The dose of corticosteroid was determined by treating physicians, often outside the study, with the daily dose reduced to the equivalent of 30-40 mg of prednisone within 5 weeks. Subsequently, treatment guidelines suggested that the dose be reduced as tolerated or the patient was withdrawn from steroids in a period not less than 6 months. RESULTS: At presentation, of the 22 patients enrolled, seven patients had nine eyes with ischaemic injury. Four eyes had improved visual acuity by two lines or more within 1 month of starting corticosteroids. No patients developed late visual loss as the steroid dose was reduced. At 1 year the visual acuity, contrast sensitivity, colour vision, and threshold perimetry were not significantly different from the 4-5 week determinations. At 1 year, there were no significant cataractous or glaucomatous changes. At 2 months, there was no difference in systemic complications between patients who received conventional dose (60-80 mg per day) or very high doses (200-1000 mg per day) of corticosteroids at the start or early in the course. CONCLUSIONS: Patients with GCA related visual loss can improve with treatment. Corticosteroids with starting doses of 60-1000 mg per day, with reduction to daily doses of 40-50 mg per day given for 4-6 weeks, and gradual dose reduction thereafter, as clinically permitted, did not result in delayed visual loss. There were no significant drug related ophthalmic complications.|Adrenal Cortex Hormones/*therapeutic use[MESH]|Aged[MESH]|Color Vision Defects/etiology[MESH]|Contrast Sensitivity/physiology[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Giant Cell Arteritis/*drug therapy/physiopathology[MESH]|Humans[MESH]|Male[MESH]|Methotrexate/therapeutic use[MESH]|Methylprednisolone/therapeutic use[MESH]|Prednisolone/therapeutic use[MESH]|Prospective Studies[MESH]|Sensory Thresholds/physiology[MESH]|Vision Disorders/*drug therapy/physiopathology[MESH]|Visual Acuity/physiology[MESH] |