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lüll Review: emotional and behavioral functioning in phenylketonuria Sullivan JE; Chang PJ Pediatr Psychol 1999[Jun]; 24 (3): 281-99OBJECTIVE: To examine 17 studies of the psychological sequelae of early-treated phenylketonuria (PKU) with emphasis on the impact of dietary control on functioning. Two questions are addressed: (1) What is the typical psychological profile associated with PKU? (2) Is emotional and behavioral disturbance more prevalent in PKU-affected individuals compared to appropriate controls? METHOD: Computerized searches of PsycINFO identified studies using behavioral, personality, and diagnostic measures. RESULTS: Findings converge upon a profile including attentional difficulties, depression, anxiety, and low self-esteem. Methodological constraints limit conclusions regarding the nature and severity of observed difficulties. A single study has used comparison groups appropriate for the simultaneous examination of the questions posed (Waisbren and Levy, 1991). CONCLUSIONS: We discuss results using a biopsychosocial framework, addressing the factors and processes that may influence emotional and behavioral functioning in this neurodevelopmental disorder. We outline potential lines of new investigation that address critical methodological factors.|*Cost of Illness[MESH]|*Personality Development[MESH]|Child[MESH]|Child Behavior Disorders/*etiology[MESH]|Chronic Disease[MESH]|Humans[MESH]|Phenylketonurias/complications/diet therapy/*psychology[MESH] |