Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Fibrous cap formation or destruction--the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation Newby AC; Zaltsman ABCardiovasc Res 1999[Feb]; 41 (2): 345-60Endothelial activation and infiltration of monocyte macrophages are essential prerequisites for fibrous cap formation, which comprises proliferation and migration of smooth muscle cells and net matrix deposition. Macrophage foam cells and endothelium act as a source of growth factors and chemoattractants for smooth muscle cells. However, growth factors alone do not stimulate smooth muscle cell proliferation or migration. This requires, in addition, the remodelling of the extracellular matrix, at least partly mediated by metalloproteinases. In particular, loss of basement membrane components and contact with the interstitial matrix appears to be required to release a brake on proliferation and migration exerted by the basement membrane. Unless there is a change in the phenotype of macrophages in advanced lesions, it is not clear why fibrous cap destruction rather than formation should take place in macrophage-rich shoulder regions of plaques. Impaired cap formation caused by smooth muscle senescence, mummification and propensity to apoptosis may be as important as increased cap destruction in promoting plaque rupture.|Animals[MESH]|Apoptosis[MESH]|Arteriosclerosis/metabolism/*pathology[MESH]|Cell Division[MESH]|Cell Movement[MESH]|Endothelium, Vascular/metabolism/*pathology[MESH]|Extracellular Matrix/metabolism/pathology[MESH]|Growth Substances/metabolism[MESH]|Humans[MESH]|Lipoproteins, LDL/metabolism[MESH]|Macrophages/pathology[MESH]|Metalloendopeptidases/metabolism[MESH]|Muscle, Smooth, Vascular/metabolism/*pathology[MESH] |