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The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells Miki T; Nagashima K; Seino SJ Mol Endocrinol 1999[Apr]; 22 (2): 113-23ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. The KATP channels in pancreatic beta-cells are thought to be critical in the regulation of glucose-induced and sulfonylurea-induced insulin secretion. Until recently, however, the molecular structure of the KATP channel was not known. Cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the sulfonylurea receptors (SUR1 and SUR2) has clarified the molecular structure of KATP channels. The pancreatic beta-cell KATP channel comprises two subunits: a Kir6.2 subunit and an SUR1 subunit. Molecular biological and molecular genetic studies have provided insights into the physiological and pathophysiological roles of the pancreatic beta-cell KATP channel in insulin secretion.|*ATP-Binding Cassette Transporters[MESH]|*Potassium Channels, Inwardly Rectifying[MESH]|Adenosine Triphosphate/*metabolism[MESH]|Animals[MESH]|Cloning, Molecular[MESH]|Humans[MESH]|Hyperinsulinism/genetics/metabolism[MESH]|Hypoglycemia/genetics/metabolism[MESH]|Insulin Secretion[MESH]|Insulin/*metabolism[MESH]|Islets of Langerhans/cytology/*metabolism[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Mice, Transgenic[MESH]|Mutation[MESH]|Nucleotides/metabolism[MESH]|Potassium Channels/*chemistry/genetics/*metabolism[MESH]|Receptors, Drug/chemistry/genetics/metabolism[MESH]|Sulfonylurea Receptors[MESH] |
