suck pdf from google scholar
PDF vom PMID10094462  :  Publisher
PDF vom PMID10094462 :   free
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text

  • DeepDyve
  • Pubget Overpricing

  • lüll
  • Protection against peroxynitrite
  • Arteel GE; Briviba K; Sies H
  • FEBS Lett 1999[Feb]; 445 (2-3): 226-30
  • Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation. Biological protection against peroxynitrite is organized in three categories: prevention, interception, and repair. Prevention is the control of the formation of peroxynitrite precursors, nitric oxide and superoxide. Interception is by direct reaction with peroxynitrite, leading to non-toxic products. In this regard, organoselenium compounds, metalloporphyrin derivatives, and peroxidases (e.g. glutathione peroxidase and myeloperoxidase) exhibit high second-order rate constants with peroxynitrite. Ebselen, like glutathione peroxidase, protects in a catalytic fashion utilizing glutathione as reductant in the peroxynitrite reductase reaction. Protection by metalloporphyrins can be maintained through glutathione or ascorbate. Repair processes remove damaged products and restitute intact biomolecules.
  • |*Nitrates[MESH]
  • |*Oxidants[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Molecular Structure[MESH]

  • *{{pmid10094462}}
    *<b>[ Protection against peroxynitrite ]</b> FEBS Lett 1999; 445(2-3) ; 226-30 Arteel GE; Briviba K; Sies H


    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    FEBS Lett

    226 2-3.445 1999