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lüll The role of CD5-expressing B cells in health and disease (review) Pers JO; Jamin C; Predine-Hug F; Lydyard P; Youinou PInt J Mol Med 1999[Mar]; 3 (3): 239-45The CD5(+) B cell population is prominent in early life and produce low avidity and, thereby, polyreactive antibodies. CD5(+) B cells are receptive to cytokines and interleukin-10 seems to be influential in the regulation of some of these CD5(+) B cells. The question of whether CD5 is a marker of activation or a molecule specific for a B cell lineage remains unresolved because evidence in support or against a separate lineage are still a matter for debate. However, we suggest the possibility of different kind of CD5(+) B cells. Indeed, activated CD5(+) B cells do proliferate, following CD5 engagement, while resting CD5(+) B cells do not. Moreover, three ligands for CD5 have, thus far, been identified but their functional effects are yet unknown. CD5(+) B cells probably play a role in setting up the idiotype network, antigen presentation and tolerance induction. B cells of most of the chronic lymphoid leukemias express CD5 molecules and, surprisingly, these cells may be expanded in non-organ-specific autoimmune diseases, such as rheumatoid arthritis or primary Sjogren's syndrome. CD5(+) B cells seems to be involved in the autoantibody production (this does not necessarily imply that pathogenic autoantibodies are produced by CD5(+) B cells) in autoimmune disease and particularly susceptible to transformation in lymphoproliferative disorders. Thus, this B cell population appears to play a key role at the crossroad of the non-organ-specific autoimmune diseases and B lymphoproliferative disorders.|Animals[MESH]|Arthritis, Rheumatoid/immunology[MESH]|Autoimmunity/*immunology[MESH]|B-Lymphocytes/*immunology/*metabolism[MESH]|CD5 Antigens/*immunology[MESH]|Cell Lineage[MESH]|Health[MESH]|Humans[MESH]|Leukemia/immunology[MESH]|Lupus Erythematosus, Systemic/immunology[MESH]|Lymphocyte Activation[MESH]|Lymphoma/immunology[MESH] |