| Nr. | Year OPEN | Title | users say | rate good | rate bad | no link | Citation |
|---|
Alzheimer s diseaseSirtuinDNA (Repair and Toxicology)Circadian clockNADBMAL1PER2Nicotinamide phosphoribosyltransferaseHeterochromatin island hypothesis14 3 3DAF16AMP activated protein kinaseSirt3Histone deacetylaseRpd3 Hda1 protein family| 1 | 2006 | Neuronal protection by sirtuins in Alzheimer's disease. | 
| + | - | nl | J Neurochem 96(2):305-13 (2006) Anekonda TS |
| 2 | 2008 | SIRT1: roles in aging and cancer. | 
| + | - | nl | BMB Rep 41(11):751-6 (2008) |
| 3 | 2009 | SIRT1, is it a tumor promoter or tumor suppressor? |
| + | - | nl | Int J Biol Sci 5(2):147-52 (2009) |
| 4 | 2009 | The conserved role of sirtuins in chromatin regulation. |
| + | - | nl | Int J Dev Biol 53(2-3):303-22 (2009) |
| 5 | 2008 | Mechanisms and molecular probes of sirtuins. |
| + | - | nl | Chem Biol 15(10):1002-13 (2008) |
| 6 | 2007 | Sirtuins in mammals: insights into their biological function. |
| + | - | nl | Biochem J 404(1):1-13 (2007) |
| 7 | 2008 | Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. |
| + | - | nl | Circ Res 102(5):519-28 (2008) |
| 8 | 2004 | Sir-viving cardiac stress: cardioprotection mediated by a longevity gene. |
| + | - | nl | Circ Res 95(10):953-6 (2004) Crow MT |
| 9 | 2005 | Small molecule regulation of Sir2 protein deacetylases. |
| + | - | nl | FEBS J 272(18):4607-16 (2005) |
| 10 | 2008 | Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. |
| + | - | nl | FEBS Lett 582(1):46-53 (2008) |
| 11 | 2006 | Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. |
| + | - | nl | Genes Dev 20(21):2913-21 (2006) |
| 12 | 2003 | How does calorie restriction work? |
| + | - | nl | Genes Dev 17(3):313-21 (2003) |
| 13 | 2000 | Sir2 links chromatin silencing, metabolism, and aging. |
| + | - | nl | Genes Dev 14(9):1021-6 (2000) |
| 14 | 2004 | Sirtuins: Sir2-related NAD-dependent protein deacetylases. |
| + | - | nl | Genome Biol 5(5):224 (2004) |
| 15 | 2008 | Acetylation in nuclear receptor signaling and the role of sirtuins. |
| + | - | nl | Mol Endocrinol 22(3):539-45 (2008) |
| 16 | 2007 | Sirtuin functions in health and disease. |
| + | - | nl | Mol Endocrinol 21(8):1745-55 (2007) |
| 17 | 2000 | The Sir2 protein family: A novel deacetylase for gene silencing and more. |
| + | - | nl | Proc Natl Acad Sci U S A 97(26):14030-2 (2000) |
| 18 | 1999 | Calorie restriction in nonhuman primates: mechanisms of reduced morbidity and mortality. |
| + | - | nl | Toxicol Sci 52(2 Suppl):56-60 (1999) |
| 19 | 2006 | Sirtuins in aging and age-related disease. |
| + | - | nl | Cell 126(2):257-68 (2006) |
| 20 | 2005 | Calorie restriction--the SIR2 connection. |
| + | - | nl | Cell 120(4):473-82 (2005) |
| 21 | 2008 | Conserved metabolic regulatory functions of sirtuins. |
| + | - | nl | Cell Metab 7(2):104-12 (2008) |
| 22 | 2005 | Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. |
| + | - | nl | FEBS Lett 579(12):2541-5 (2005) |
| 23 | 2011 | Identification of specific and semi-specific SIRT inhibitors through computer-aided studies. |
| + | - | nl | Aging (Albany NY) 3(9):819-20 (2011) |
| 24 | 2011 | Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. |
| + | - | nl | Aging (Albany NY) 3(9):829-35 (2011) |
| 25 | 2011 | Does hypothalamic SIRT1 regulate aging? |
| + | - | nl | Aging (Albany NY) 3(3):325-8 (2011) |
| 26 | 2011 | Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. |
| + | - | nl | Aging (Albany NY) 3(4):444-9 (2011) |
| 27 | 2010 | A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1. |
| + | - | nl | Altern Med Rev 15(3):245-63 (2010) |
| 28 | 2010 | Sirtuin chemical mechanisms. |
| + | - | nl | Biochim Biophys Acta 1804(8):1591-603 (2010) |
| 29 | 2010 | "Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. |
| + | - | nl | Biochim Biophys Acta 1804(8):1584-90 (2010) |
| 30 | 2010 | Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction. |
| + | - | nl | Biochim Biophys Acta 1804(8):1567-75 (2010) |
| 31 | 2010 | Structural basis for sirtuin function: what we know and what we don't. |
| + | - | nl | Biochim Biophys Acta 1804(8):1604-16 (2010) |
| 32 | 2009 | From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis. |
| + | - | nl | Biochim Biophys Acta 1790(10):997-1004 (2009) |
| 33 | 2006 | A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins. |
| + | - | nl | Cell Cycle 5(22):2588-91 (2006) |
| 34 | 2010 | At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. |
| + | - | nl | Cell Cycle 9(10):1907-12 (2010) |
| 35 | 2008 | Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. | 
| + | - | nl | Cell Cycle 7(23):3669-79 (2008) |
| 36 | 2010 | Sirtuins and their relevance to the kidney. |
| + | - | nl | J Am Soc Nephrol 21(10):1620-7 (2010) |
| 37 | 2010 | The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. |
| + | - | nl | Endocr Rev 31(2):194-223 (2010) |
| 38 | 2008 | Transcriptional targets of sirtuins in the coordination of mammalian physiology. |
| + | - | nl | Curr Opin Cell Biol 20(3):303-9 (2008) |
| 39 | 2011 | Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis. |
| + | - | nl | Int J Mol Sci 12(9):6226-39 (2011) |
| 40 | 2008 | The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. |
| + | - | nl | Nat Rev Mol Cell Biol 9(3):206-18 (2008) |
