| Nr. | Year OPEN | Title | users say> | rate good | rate bad | no link | Citation |
SepsisADHCorticosteroidsInfusion therapyEndothelial dysfunctionSIRS (Systemic inflammatory response syndrome)Neutrophil extracellular trapsInterleukin27Blood vessles (Vascular access)Staphylococcus aureusNK cellsProtein CBlood vessels (Permeability)GlycocalyxHeparan sulfateSyndecanApoptosisProcalcitoninAntiinflammatory compoundsPAR1Drotrecogin alphaAntioxidantsGlucocorticoidsStatics and trial designErythropoietinArtificial ventilation (BASKET)Receptor (RAGE)Neutropenia (Fever neutropenic)Kupffer cellC5aRegulatory T cellStatin| 1 | 2010 | Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI)). | 
| + | - | nl | Ger Med Sci 8(-):Doc14 (2010) |
| 2 | 2003 | Advances in the understanding of clinical manifestations and therapy of severe sepsis: an update for critical care nurses. | 
| + | - | nl | Am J Crit Care 12(2):120-33; quiz 134-5 (2003) |
| 3 | 2008 | Surviving sepsis: a guide to the guidelines. | 
| + | - | nl | Crit Care 12(3):162 (2008) |
| 4 | 2007 | Diagnosis and treatment of severe sepsis. | 
| + | - | nl | Crit Care 11 Suppl 5(-):S2 (2007) |
| 5 | 2006 | Rescue therapy in septic shock--is terlipressin the last frontier? | 
| + | - | nl | Crit Care 10(2):131 (2006) Leone M |
| 6 | 2005 | Clinical review: Vasopressin and terlipressin in septic shock patients. | 
| + | - | nl | Crit Care 9(2):212-22 (2005) Delmas A |
| 7 | 2004 | Bench-to-bedside review: sepsis is a disease of the microcirculation. | 
| + | - | nl | Crit Care 8(6):462-8 (2004) Spronk PE |
| 8 | 2004 | Clinical review: corticotherapy in sepsis. | 
| + | - | nl | Crit Care 8(2):122-9 (2004) |
| 9 | 2003 | Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide. | 
| + | - | nl | Crit Care 7(5):359-73 (2003) |
| 10 | 2002 | Clinical review: Hypertonic saline resuscitation in sepsis. | 
| + | - | nl | Crit Care 6(5):418-23 (2002) |
| 11 | 2002 | The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock. | 
| + | - | nl | Crit Care 6(5):384-6 (2002) |
| 12 | 2002 | The International Sepsis Forum's controversies in sepsis: corticosteroids should be used to treat septic shock. | 
| + | - | nl | Crit Care 6(5):381-3 (2002) |
| 13 | 2003 | Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction? | 
| + | - | nl | Crit Care 7(2):130-8 (2003) |
| 14 | 2003 | Science review: role of coagulation protease cascades in sepsis. | 
| + | - | nl | Crit Care 7(2):123-9 (2003) Riewald M |
| 15 | 2002 | Clinical review: Myocardial depression in sepsis and septic shock. | 
| + | - | nl | Crit Care 6(6):500-8 (2002) |
| 16 | 2006 | Critical care in the emergency department: severe sepsis and septic shock. | 
| + | - | nl | Emerg Med J 23(9):713-7 (2006) |
| 17 | 2006 | The pathogenesis and molecular biology of sepsis. | 
| + | - | nl | Crit Care Resusc 8(3):227-9 (2006) |
| 18 | 2005 | Recent insights into the pathogenesis of severe sepsis. | 
| + | - | nl | Crit Care Resusc 7(1):32-9 (2005) |
| 19 | 2004 | Metabolic acidosis in patients with sepsis: epiphenomenon or part of the pathophysiology? | 
| + | - | nl | Crit Care Resusc 6(3):197-203 (2004) |
| 20 | 2003 | Catecholamines in the treatment of septic shock: effects beyond perfusion. | 
| + | - | nl | Crit Care Resusc 5(4):270-6 (2003) |
| 21 | 2006 | Role of KATP channels in sepsis. | 
| + | - | nl | Cardiovasc Res 72(2):220-30 (2006) |
| 22 | 1998 | The haematological manifestations of sepsis. | 
| + | - | nl | J Antimicrob Chemother 41 Suppl A(-):17-24 (1998) |
| 23 | 1998 | Cardiovascular alterations in septic shock. | 
| + | - | nl | J Antimicrob Chemother 41 Suppl A(-):9-15 (1998) |
| 24 | 2003 | Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. | 
| + | - | nl | Clin Microbiol Rev 16(3):379-414 (2003) |
| 25 | 1993 | Gram-negative sepsis: a dilemma of modern medicine. | 
| + | - | nl | Clin Microbiol Rev 6(1):57-68 (1993) |
| 26 | 1990 | Quantitative aspects of septicemia. | 
| + | - | nl | Clin Microbiol Rev 3(3):269-79 (1990) |
| 27 | 2009 | Statins for sepsis: a critical and updated review. | 
| + | - | nl | Clin Microbiol Infect 15(4):325-34 (2009) |
| 28 | 2009 | Activated protein C for the treatment of severe sepsis. | 
| + | - | nl | Clin Microbiol Infect 15(4):319-24 (2009) |
| 29 | 2009 | The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis. | 
| + | - | nl | Clin Microbiol Infect 15(4):308-18 (2009) |
| 30 | 2009 | Non-antibiotic strategies for sepsis. | 
| + | - | nl | Clin Microbiol Infect 15(4):302-7 (2009) |
| 31 | 2008 | Sepsis: rethinking the approach to clinical research. | 
| + | - | nl | J Leukoc Biol 83(3):471-82 (2008) |
| 32 | 2008 | Inflammation, endothelium, and coagulation in sepsis. | 
| + | - | nl | J Leukoc Biol 83(3):536-45 (2008) |
| 33 | 2008 | Sepsis: a clinical update. | 
| + | - | nl | Clin J Am Soc Nephrol 3(2):571-7 (2008) |
| 34 | 2008 | Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis. | 
| + | - | nl | J Thromb Haemost 6(3):415-20 (2008) |
| 35 | 2002 | The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). | 
| + | - | nl | Int J Mol Med 9(5):443-9 (2002) |
| 36 | 2000 | Mechanism of hepatocellular dysfunction during sepsis: the role of gut-derived norepinephrine (review). | 
| + | - | nl | Int J Mol Med 5(5):457-65 (2000) |
| 37 | 2005 | Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity. | 
| + | - | nl | CMAJ 173(9):1054-65 (2005) |
| 38 | 2008 | Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. | 
| + | - | nl | Acad Emerg Med 15(5):399-413 (2008) |
| 39 | 2007 | New therapies for sepsis: focus on the interleukin (IL)12 family member IL27. | 
| + | - | nl | Ann Rheum Dis 66 Suppl 3(-):iii29-31 (2007) |
| 40 | 2007 | Physiological monitoring for critically ill patients: testing a predictive model for the early detection of sepsis. | 
| + | - | nl | Am J Crit Care 16(2):122-30; quiz 131 (2007) |
| 41 | 2007 | Sepsis: definition, epidemiology, and diagnosis. | 
| + | - | nl | BMJ 335(7625):879-83 (2007) |
| 42 | 2007 | Management of sepsis. | 
| + | - | nl | BMJ 335(7626):929-32 (2007) |
| 43 | 2011 | Managing bloodstream infections in patients who have short-term central venous catheters. | 
| + | - | nl | Cleve Clin J Med 78(1):10-7 (2011) |
| 44 | 2010 | The host response to sepsis and developmental impact. | 
| + | - | nl | Pediatrics 125(5):1031-41 (2010) |
| 45 | 2010 | Mechanisms and regulation of the gene-expression response to sepsis. | 
| + | - | nl | Pediatrics 125(6):1248-58 (2010) |
| 46 | 2007 | Managing the nervous system effects of sepsis. | 
| + | - | nl | Chest 131(5):1273-4 (2007) |
| 47 | 2008 | Fluid therapy in resuscitated sepsis: less is more. | 
| + | - | nl | Chest 133(1):252-63 (2008) |
| 48 | 2009 | Staphylococcus aureus bloodstream infections: definitions and treatment. | 
| + | - | nl | Clin Infect Dis 48 Suppl 4(-):S254-9 (2009) |
| 49 | 2009 | Clinical consensus conference: survey on Gram-positive bloodstream infections with a focus on Staphylococcus aureus. | 
| + | - | nl | Clin Infect Dis 48 Suppl 4(-):S260-70 (2009) |
| 50 | 2009 | Safety and efficacy of corticosteroids for the treatment of septic shock: A systematic review and meta-analysis. | 
| + | - | nl | Clin Infect Dis 49(1):93-101 (2009) |
| 51 | 2011 | The role of natural killer cells in sepsis. | 
| + | - | nl | J Biomed Biotechnol 2011(-):986491 (2011) |
| 52 | 2005 | Effects of recombinant human activated protein C in human models of endotoxin administration. | 
| + | - | nl | Proc Am Thorac Soc 2(3):243-7 (2005) |
| 53 | 2010 | Sepsis-induced degradation of endothelial glycocalix. | 
| + | - | nl | ScientificWorldJournal 10(-):917-23 (2010) |
| 54 | 2010 | Insights into sepsis therapeutic design based on the apoptotic death pathway. | 
| + | - | nl | J Pharmacol Sci 114(4):354-65 (2010) |
| 55 | 2006 | Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy. | 
| + | - | nl | J Pharmacol Sci 101(3):189-98 (2006) |
| 56 | 2010 | Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target. | 
| + | - | nl | Br J Pharmacol 159(2):253-64 (2010) |
| 57 | 2009 | Protective mechanisms of activated protein C in severe inflammatory disorders. | 
| + | - | nl | Br J Pharmacol 158(4):1034-47 (2009) |
| 58 | 2003 | The enigma of sepsis. | 
| + | - | nl | J Clin Invest 112(4):460-7 (2003) |
| 59 | 2004 | Toward resolving the challenges of sepsis diagnosis. | 
| + | - | nl | Clin Chem 50(8):1301-14 (2004) |
| 60 | 2009 | Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. | 
| + | - | nl | Am J Respir Crit Care Med 180(9):861-6 (2009) |
| 61 | 2011 | Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. | 
| + | - | nl | Crit Care 15(1):R58 (2011) |
| 62 | 2010 | Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis. | 
| + | - | nl | Crit Care 14(4):230 (2010) |
| 63 | 2010 | Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective. | 
| + | - | nl | Crit Care 14(4):R134 (2010) |
| 64 | 2010 | Corticosteroids for sepsis: registry versus Cochrane systematic review! | 
| + | - | nl | Crit Care 14(4):185 (2010) |
| 65 | 2010 | Bench to bedside: A role for erythropoietin in sepsis. | 
| + | - | nl | Crit Care 14(4):227 (2010) |
| 66 | 2010 | Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry. | 
| + | - | nl | Crit Care 14(3):R102 (2010) |
| 67 | 2010 | Cerebral perfusion in sepsis. | 
| + | - | nl | Crit Care 14(2):215 (2010) |
| 68 | 2010 | Sepsis biomarkers: a review. | 
| + | - | nl | Crit Care 14(1):R15 (2010) |
| 69 | 2009 | Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock--does the dose matter? | 
| + | - | nl | Crit Care 13(3):214 (2009) |
| 70 | 2009 | Bench-to-bedside review: ventilatory abnormalities in sepsis. | 
| + | - | nl | Crit Care 13(1):202 (2009) |
| 71 | 2008 | Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. | 
| + | - | nl | Crit Care 12(1):201 (2008) |
| 72 | 2008 | Cellular processes in sepsis. | 
| + | - | nl | Swiss Med Wkly 138(43-44):629-34 (2008) |
| 73 | 2007 | Management of severe sepsis of abdominal origin. | 
| + | - | nl | Scand J Surg 96(3):184-96 (2007) |
| 74 | 2009 | Revisiting steroid treatment for septic shock: molecular actions and clinical effects--a review. | 
| + | - | nl | Mem Inst Oswaldo Cruz 104(4):531-48 (2009) |
| 75 | 2010 | Molecular microbiological methods in the diagnosis of neonatal sepsis. | 
| + | - | nl | Expert Rev Anti Infect Ther 8(9):1037-48 (2010) |
| 76 | 2011 | Biomarkers for pediatric sepsis and septic shock. | 
| + | - | nl | Expert Rev Anti Infect Ther 9(1):71-9 (2011) |
| 77 | 2009 | Treatment of septic shock and use of drotrecogin alfa (activated) in children. | 
| + | - | nl | Expert Rev Anti Infect Ther 7(7):769-72 (2009) |
| 78 | 2007 | Pharmacologic support of infants and children in septic shock. | 
| + | - | nl | J Pediatr (Rio J) 83(2 Suppl):S36-45 (2007) |
| 79 | 2007 | New guidelines for the clinical management of febrile neutropenia and sepsis in pediatric oncology patients. | 
| + | - | nl | J Pediatr (Rio J) 83(2 Suppl):S54-63 (2007) |
| 80 | 2007 | What tests can help diagnose and estimate the severity of sepsis? | 
| + | - | nl | J Pediatr (Rio J) 83(4):297-8 (2007) Lacroix J |
| 81 | 2007 | Adrenal function in sepsis and septic shock. | 
| + | - | nl | J Pediatr (Rio J) 83(5 Suppl):S155-62 (2007) |
| 82 | 2010 | Recent insights into the pathogenesis of bacterial sepsis. | 
| + | - | nl | Neth J Med 68(4):147-52 (2010) |
| 83 | 2002 | Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. | 
| + | - | nl | J Leukoc Biol 72(2):239-48 (2002) |
| 84 | 2004 | The chronic consequences of severe sepsis. | 
| + | - | nl | J Leukoc Biol 75(3):408-12 (2004) |
| 85 | 2004 | The roles of insulin and hyperglycemia in sepsis pathogenesis. | 
| + | - | nl | J Leukoc Biol 75(3):413-21 (2004) |
| 86 | 2003 | A key role of C5a/C5aR activation for the development of sepsis. | 
| + | - | nl | J Leukoc Biol 74(6):966-70 (2003) |
| 87 | 2009 | Editorial: Mouse models to study sepsis syndrome in humans. | 
| + | - | nl | J Leukoc Biol 86(2):199-201 (2009) Warren HS |
| 88 | 2008 | Regulatory T cell populations in sepsis and trauma. | 
| + | - | nl | J Leukoc Biol 83(3):523-35 (2008) |
| 89 | 2004 | The heart and circulation in severe sepsis. | 
| + | - | nl | Br J Anaesth 93(1):114-20 (2004) |
| 90 | 2008 | Statins and sepsis. | 
| + | - | nl | Br J Anaesth 100(3):288-98 (2008) |