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  • PI3K
  • Protein kinase B Akt
  • PAR4
  • Phosphatidylinositol phosphate
  • Rac
  • Cell migration
  • ARF
  • PIKE
  • Endothelial dysfunction
  • Insulin resistance
  • p110alpha
  • Wortmannin
  • LY294002
  • PI103
  • GDC0941
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    Citation
    12007The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.



    +-nlCurr Genomics 8(5):271-306 (2007)
    22009Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy.



    +-nlMol Cancer Ther 8(1):1-9 (2009)
    32008Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy.



    +-nlCancer Sci 99(9):1734-40 (2008)
    42006The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target.



    +-nlCancer Res 66(6):2889-92 (2006)
    52003The phosphoinositide (PI) 3-kinase family.



    +-nlJ Cell Sci 116(Pt 15):3037-40 (2003)
    62001Phosphoinositide 3-kinase signalling pathways.



    +-nlJ Cell Sci 114(Pt 8):1439-45 (2001)
    71992Phosphatidylinositol 3-kinase: a novel effector.



    +-nlCell Growth Differ 3(10):747-52 (1992)
    82001Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.



    +-nlEndocr Relat Cancer 8(3):237-48 (2001)
    91999Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways.



    +-nlJ Biol Chem 274(14):9129-32 (1999)
    101999The role of phosphoinositide 3-kinase lipid products in cell function.



    +-nlJ Biol Chem 274(13):8347-50 (1999)
    112007Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.



    +-nlJ Endocrinol 194(2):243-56 (2007)
    121998PI 3-kinase.



    +-nlCurr Biol 8(23):R828 (1998)
    132009PI3K/PTEN signaling in angiogenesis and tumorigenesis.



    +-nlAdv Cancer Res 102(-):19-65 (2009)
    142004Molecular targeting: PI3 kinase pathway.



    +-nlAnn Oncol 15 Suppl 4(-):iv233-9 (2004)
    152010Status of PI3K inhibition and biomarker development in cancer therapeutics.



    +-nlAnn Oncol 21(4):683-91 (2010)
    162010Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.



    +-nlBiochim Biophys Acta 1804(3):533-40 (2010)
    172003Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.



    +-nlCell Cycle 2(4):339-45 (2003)
    182007New functions for PI3K in the control of cell division.



    +-nlCell Cycle 6(14):1696-8 (2007)
    192009Phosphoinositide 3-kinase signalling in the vascular system.



    +-nlCardiovasc Res 82(2):261-71 (2009)
    202008The regulation of cell motility and chemotaxis by phospholipid signaling.



    +-nlJ Cell Sci 121(Pt 5):551-9 (2008)
    212010Multiple functions of phosphoinositide-3 kinase enhancer (PIKE).



    +-nlScientificWorldJournal 10(-):613-23 (2010)
    222008An integrated view of insulin resistance and endothelial dysfunction.



    +-nlEndocrinol Metab Clin North Am 37(3):685-711, ix-x (2008)
    232010Targeting the PI3K signaling pathway in cancer.



    +-nlCurr Opin Genet Dev 20(1):87-90 (2010)
    242009PI 3-kinase and cancer: changing accents.



    +-nlCurr Opin Genet Dev 19(1):12-7 (2009)
    252010Drugging the PI3 kinome: from chemical tools to drugs in the clinic.



    +-nlCancer Res 70(6):2146-57 (2010)



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