| Nr. | Year OPEN | Title | users say> | rate good | rate bad | no link | Citation |
HIF1alpha und HIF1 (BASKET)HSP90RACK1Neoplasia (Tumor biology and immunology)Kidney (Development)Histone deacetylaseRemodelingNitric oxide NOProlyl hydroxylasesPHD protein domainIschemia reperfusionNeoplasia (Carcinogenesis)Mitochondria (BASKET)Redox (BASKET)VHLMycErythropoiesisHIF2alphaPHD2FIH1Chuvash polycythemiaOxygen (Hypoxia)MTORTuberculosisUnfolded protein responseHistone demethylaseJMJD1A KDM3AKidney (Chronic renal failure)Kidney (Fibrosis)Kidney (Microcirculation)Sphingosine1 phosphateStem cell (Neoplasia)Asparaginyl hydroxylationEpigeneticsInflammation (BASKET)Transcription factor (BASKET)MorphogenesisEmbryology (BASKET)Erythropoietin| 1 | 2002 | Oxygen-dependent and -independent regulation of HIF-1alpha. | 
| + | - | nl | J Korean Med Sci 17(5):581-8 (2002) |
| 2 | 2007 | Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. | 
| + | - | nl | Yale J Biol Med 80(2):51-60 (2007) |
| 3 | 2004 | HIF-1: the knowns and unknowns of hypoxia sensing. | 
| + | - | nl | Acta Biochim Pol 51(3):563-85 (2004) |
| 4 | 2004 | Hypoxia inducible factor-1alpha as a cancer drug target. | 
| + | - | nl | Mol Cancer Ther 3(5):647-54 (2004) |
| 5 | 2005 | Targeting hypoxia and angiogenesis through HIF-1alpha inhibition. | 
| + | - | nl | Cancer Biol Ther 4(10):1055-62 (2005) |
| 6 | 2004 | Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade. | 
| + | - | nl | Cancer Biol Ther 3(6):503-4 (2004) |
| 7 | 2004 | HIF-1: an oxygen and metal responsive transcription factor. | 
| + | - | nl | Cancer Biol Ther 3(1):29-35 (2004) |
| 8 | 2006 | Inhibiting hypoxia-inducible factor 1 for cancer therapy. | 
| + | - | nl | Mol Cancer Res 4(9):601-5 (2006) |
| 9 | 2009 | HIF at a glance. | 
| + | - | nl | J Cell Sci 122(Pt 8):1055-7 (2009) |
| 10 | 2003 | HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels. | 
| + | - | nl | J Cell Sci 116(Pt 15):3041-9 (2003) |
| 11 | 2006 | The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling. | 
| + | - | nl | EMBO Rep 7(1):41-5 (2006) |
| 12 | 2004 | The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. | 
| + | - | nl | Genes Dev 18(18):2183-94 (2004) |
| 13 | 2003 | Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. | 
| + | - | nl | Genes Dev 17(21):2614-23 (2003) |
| 14 | 2000 | HIF-1 and human disease: one highly involved factor. | 
| + | - | nl | Genes Dev 14(16):1983-91 (2000) |
| 15 | 2003 | Hypoxia-inducible factor and its biomedical relevance. | 
| + | - | nl | J Biol Chem 278(22):19575-8 (2003) |
| 16 | 2001 | HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. | 
| + | - | nl | Cell 107(1):1-3 (2001) |
| 17 | 1999 | Perspectives on oxygen sensing. | 
| + | - | nl | Cell 98(3):281-4 (1999) |
| 18 | 2004 | Physiological and pathological responses to hypoxia. | 
| + | - | nl | Am J Pathol 164(6):1875-82 (2004) |
| 19 | 2002 | Oxygen-dependent signaling in pulmonary vascular smooth muscle. | 
| + | - | nl | Am J Physiol Lung Cell Mol Physiol 283(4):L671-7 (2002) |
| 20 | 2006 | Hypoxia-inducible factors in the kidney. | 
| + | - | nl | Am J Physiol Renal Physiol 291(2):F271-81 (2006) |
| 21 | 2008 | The HIF/VHL pathway: from oxygen sensing to innate immunity. | 
| + | - | nl | Am J Respir Cell Mol Biol 38(3):251-5 (2008) |
| 22 | 2007 | Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps. | 
| + | - | nl | Biochem J 408(2):e5-6 (2007) Metzen E |
| 23 | 2008 | Hypoxia-inducible factor: roles in development, physiology, and disease. | 
| + | - | nl | Cell Death Differ 15(4):619-20 (2008) |
| 24 | 2008 | Biology of HIF-1alpha. | 
| + | - | nl | Cell Death Differ 15(4):621-7 (2008) |
| 25 | 2008 | Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing. | 
| + | - | nl | Eur Respir J 32(1):210-7 (2008) |
| 26 | 2005 | Oxygen sensing. | 
| + | - | nl | Haematologica 90(1):8-12 (2005) |
| 27 | 2003 | HIF-1: an oxygen response system with special relevance to the kidney. | 
| + | - | nl | J Am Soc Nephrol 14(11):2712-22 (2003) |
| 28 | 2004 | The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. | 
| + | - | nl | J Clin Pathol 57(10):1009-14 (2004) |
| 29 | 2005 | Acute oxygen-sensing mechanisms. | 
| + | - | nl | N Engl J Med 353(19):2042-55 (2005) |
| 30 | 2005 | Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. | 
| + | - | nl | Neuro Oncol 7(2):134-53 (2005) |
| 31 | 2002 | Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. | 
| + | - | nl | Respir Res 3(-):26 (2002) |
| 32 | 2004 | Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. | 
| + | - | nl | Exp Mol Med 36(1):1-12 (2004) |
| 33 | 2007 | RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. | 
| + | - | nl | Cell Cycle 6(6):656-9 (2007) |
| 34 | 2007 | HIF-1-regulated glucose metabolism: a key to apoptosis resistance? | 
| + | - | nl | Cell Cycle 6(7):790-2 (2007) |
| 35 | 2010 | Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans. | 
| + | - | nl | Physiology (Bethesda) 25(5):272-9 (2010) |
| 36 | 2004 | Hydroxylation of HIF-1: oxygen sensing at the molecular level. | 
| + | - | nl | Physiology (Bethesda) 19(-):176-82 (2004) |
| 37 | 2009 | Regulation of oxygen homeostasis by hypoxia-inducible factor 1. | 
| + | - | nl | Physiology (Bethesda) 24(-):97-106 (2009) |
| 38 | 2009 | HIF in kidney disease and development. | 
| + | - | nl | J Am Soc Nephrol 20(9):1877-87 (2009) |
| 39 | 2011 | Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors. | 
| + | - | nl | J Biomed Biotechnol 2011(-):197946 (2011) |
| 40 | 2010 | Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. | 
| + | - | nl | Cardiovasc Res 86(2):236-42 (2010) |
| 41 | 2007 | Nitric oxide and superoxide: interference with hypoxic signaling. | 
| + | - | nl | Cardiovasc Res 75(2):275-82 (2007) |
| 42 | 2008 | Role and regulation of prolyl hydroxylase domain proteins. | 
| + | - | nl | Cell Death Differ 15(4):635-41 (2008) |
| 43 | 2008 | Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. | 
| + | - | nl | Cell Death Differ 15(4):686-90 (2008) |
| 44 | 2008 | The role of hypoxia-inducible factors in tumorigenesis. | 
| + | - | nl | Cell Death Differ 15(4):678-85 (2008) |
| 45 | 2008 | Mitochondrial complex III regulates hypoxic activation of HIF. | 
| + | - | nl | Cell Death Differ 15(4):660-6 (2008) |
| 46 | 2008 | The VHL tumor suppressor and HIF: insights from genetic studies in mice. | 
| + | - | nl | Cell Death Differ 15(4):650-9 (2008) |
| 47 | 2008 | Turn me on: regulating HIF transcriptional activity. | 
| + | - | nl | Cell Death Differ 15(4):642-9 (2008) |
| 48 | 2008 | Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation. | 
| + | - | nl | Cell Death Differ 15(4):672-7 (2008) |
| 49 | 2009 | Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. | 
| + | - | nl | Blood 114(10):2015-9 (2009) |
| 50 | 2011 | Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: drug discovery for targeting the tumor microenvironment. | 
| + | - | nl | J Pharmacol Sci 115(4):446-52 (2011) |
| 51 | 2011 | Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy. | 
| + | - | nl | J Pharmacol Sci 115(4):440-5 (2011) |
| 52 | 2011 | Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes. | 
| + | - | nl | J Pharmacol Sci 115(4):453-8 (2011) |
| 53 | 2004 | Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools. | 
| + | - | nl | J Pharmacol Sci 94(3):221-32 (2004) |
| 54 | 2009 | Drug discovery for overcoming chronic kidney disease (CKD): prolyl-hydroxylase inhibitors to activate hypoxia-inducible factor (HIF) as a novel therapeutic approach in CKD. | 
| + | - | nl | J Pharmacol Sci 109(1):24-31 (2009) |
| 55 | 2003 | HIF hydroxylation and the mammalian oxygen-sensing pathway. | 
| + | - | nl | J Clin Invest 111(6):779-83 (2003) |
| 56 | 2010 | HIF-1: upstream and downstream of cancer metabolism. | 
| + | - | nl | Curr Opin Genet Dev 20(1):51-6 (2010) |
| 57 | 2009 | When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy. | 
| + | - | nl | Cancer Res 69(9):3723-6 (2009) |
| 58 | 2010 | PHD2 in tumour angiogenesis. | 
| + | - | nl | Br J Cancer 103(1):1-5 (2010) |
| 59 | 2010 | Hypoxia inducible factors in cancer stem cells. | 
| + | - | nl | Br J Cancer 102(5):789-95 (2010) |
| 60 | 2003 | Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. | 
| + | - | nl | Eur J Biochem 270(5):781-90 (2003) |
| 61 | 2003 | The subtle side to hypoxia inducible factor (HIFalpha) regulation. | 
| + | - | nl | Eur J Biochem 270(5):791-8 (2003) |
| 62 | 2004 | O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. | 
| + | - | nl | J Appl Physiol 96(3):1173-7; discussion 1170-2 (2004) |
| 63 | 2007 | Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1. | 
| + | - | nl | Exp Physiol 92(6):988-91 (2007) |
| 64 | 2010 | Inflammation, HIF-1, and the epigenetics that follows. | 
| + | - | nl | Mediators Inflamm 2010(-):263914 (2010) |
| 65 | 2011 | Epigenetics: new questions on the response to hypoxia. | 
| + | - | nl | Int J Mol Sci 12(7):4705-21 (2011) |
| 66 | 2010 | Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction. | 
| + | - | nl | Nucleic Acids Res 38(7):2332-45 (2010) |
| 67 | 2008 | The role of oxygen availability in embryonic development and stem cell function. | 
| + | - | nl | Nat Rev Mol Cell Biol 9(4):285-96 (2008) |
| 68 | 2010 | Hypoxic regulation of erythropoiesis and iron metabolism. | 
| + | - | nl | Am J Physiol Renal Physiol 299(1):F1-13 (2010) |