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  • HIF1alpha und HIF1 (BASKET)
  • HSP90
  • RACK1
  • Neoplasia (Tumor biology and immunology)
  • Kidney (Development)
  • Histone deacetylase
  • Remodeling
  • Nitric oxide NO
  • Prolyl hydroxylases
  • PHD protein domain
  • Ischemia reperfusion
  • Neoplasia (Carcinogenesis)
  • Mitochondria (BASKET)
  • Redox (BASKET)
  • VHL
  • Myc
  • Erythropoiesis
  • HIF2alpha
  • PHD2
  • FIH1
  • Chuvash polycythemia
  • Oxygen (Hypoxia)
  • MTOR
  • Tuberculosis
  • Unfolded protein response
  • Histone demethylase
  • JMJD1A KDM3A
  • Kidney (Chronic renal failure)
  • Kidney (Fibrosis)
  • Kidney (Microcirculation)
  • Sphingosine1 phosphate
  • Stem cell (Neoplasia)
  • Asparaginyl hydroxylation
  • Epigenetics
  • Inflammation (BASKET)
  • Transcription factor (BASKET)
  • Morphogenesis
  • Embryology (BASKET)
  • Erythropoietin
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    Citation
    12002Oxygen-dependent and -independent regulation of HIF-1alpha.



    +-nlJ Korean Med Sci 17(5):581-8 (2002)
    22007Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia.



    +-nlYale J Biol Med 80(2):51-60 (2007)
    32004HIF-1: the knowns and unknowns of hypoxia sensing.



    +-nlActa Biochim Pol 51(3):563-85 (2004)
    42004Hypoxia inducible factor-1alpha as a cancer drug target.



    +-nlMol Cancer Ther 3(5):647-54 (2004)
    52005Targeting hypoxia and angiogenesis through HIF-1alpha inhibition.



    +-nlCancer Biol Ther 4(10):1055-62 (2005)
    62004Small molecule-mediated anti-cancer therapy via hypoxia-inducible factor-1 blockade.



    +-nlCancer Biol Ther 3(6):503-4 (2004)
    72004HIF-1: an oxygen and metal responsive transcription factor.



    +-nlCancer Biol Ther 3(1):29-35 (2004)
    82006Inhibiting hypoxia-inducible factor 1 for cancer therapy.



    +-nlMol Cancer Res 4(9):601-5 (2006)
    92009HIF at a glance.



    +-nlJ Cell Sci 122(Pt 8):1055-7 (2009)
    102003HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.



    +-nlJ Cell Sci 116(Pt 15):3041-9 (2003)
    112006The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling.



    +-nlEMBO Rep 7(1):41-5 (2006)
    122004The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.



    +-nlGenes Dev 18(18):2183-94 (2004)
    132003Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor.



    +-nlGenes Dev 17(21):2614-23 (2003)
    142000HIF-1 and human disease: one highly involved factor.



    +-nlGenes Dev 14(16):1983-91 (2000)
    152003Hypoxia-inducible factor and its biomedical relevance.



    +-nlJ Biol Chem 278(22):19575-8 (2003)
    162001HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.



    +-nlCell 107(1):1-3 (2001)
    171999Perspectives on oxygen sensing.



    +-nlCell 98(3):281-4 (1999)
    182004Physiological and pathological responses to hypoxia.



    +-nlAm J Pathol 164(6):1875-82 (2004)
    192002Oxygen-dependent signaling in pulmonary vascular smooth muscle.



    +-nlAm J Physiol Lung Cell Mol Physiol 283(4):L671-7 (2002)
    202006Hypoxia-inducible factors in the kidney.



    +-nlAm J Physiol Renal Physiol 291(2):F271-81 (2006)
    212008The HIF/VHL pathway: from oxygen sensing to innate immunity.



    +-nlAm J Respir Cell Mol Biol 38(3):251-5 (2008)
    222007Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps.



    +-nlBiochem J 408(2):e5-6 (2007) Metzen E
    232008Hypoxia-inducible factor: roles in development, physiology, and disease.



    +-nlCell Death Differ 15(4):619-20 (2008)
    242008Biology of HIF-1alpha.



    +-nlCell Death Differ 15(4):621-7 (2008)
    252008Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing.



    +-nlEur Respir J 32(1):210-7 (2008)
    262005Oxygen sensing.



    +-nlHaematologica 90(1):8-12 (2005)
    272003HIF-1: an oxygen response system with special relevance to the kidney.



    +-nlJ Am Soc Nephrol 14(11):2712-22 (2003)
    282004The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis.



    +-nlJ Clin Pathol 57(10):1009-14 (2004)
    292005Acute oxygen-sensing mechanisms.



    +-nlN Engl J Med 353(19):2042-55 (2005)
    302005Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.



    +-nlNeuro Oncol 7(2):134-53 (2005)
    312002Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology.



    +-nlRespir Res 3(-):26 (2002)
    322004Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions.



    +-nlExp Mol Med 36(1):1-12 (2004)
    332007RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.



    +-nlCell Cycle 6(6):656-9 (2007)
    342007HIF-1-regulated glucose metabolism: a key to apoptosis resistance?



    +-nlCell Cycle 6(7):790-2 (2007)
    352010Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans.



    +-nlPhysiology (Bethesda) 25(5):272-9 (2010)
    362004Hydroxylation of HIF-1: oxygen sensing at the molecular level.



    +-nlPhysiology (Bethesda) 19(-):176-82 (2004)
    372009Regulation of oxygen homeostasis by hypoxia-inducible factor 1.



    +-nlPhysiology (Bethesda) 24(-):97-106 (2009)
    382009HIF in kidney disease and development.



    +-nlJ Am Soc Nephrol 20(9):1877-87 (2009)
    392011Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.



    +-nlJ Biomed Biotechnol 2011(-):197946 (2011)
    402010Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.



    +-nlCardiovasc Res 86(2):236-42 (2010)
    412007Nitric oxide and superoxide: interference with hypoxic signaling.



    +-nlCardiovasc Res 75(2):275-82 (2007)
    422008Role and regulation of prolyl hydroxylase domain proteins.



    +-nlCell Death Differ 15(4):635-41 (2008)
    432008Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion.



    +-nlCell Death Differ 15(4):686-90 (2008)
    442008The role of hypoxia-inducible factors in tumorigenesis.



    +-nlCell Death Differ 15(4):678-85 (2008)
    452008Mitochondrial complex III regulates hypoxic activation of HIF.



    +-nlCell Death Differ 15(4):660-6 (2008)
    462008The VHL tumor suppressor and HIF: insights from genetic studies in mice.



    +-nlCell Death Differ 15(4):650-9 (2008)
    472008Turn me on: regulating HIF transcriptional activity.



    +-nlCell Death Differ 15(4):642-9 (2008)
    482008Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation.



    +-nlCell Death Differ 15(4):672-7 (2008)
    492009Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.



    +-nlBlood 114(10):2015-9 (2009)
    502011Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: drug discovery for targeting the tumor microenvironment.



    +-nlJ Pharmacol Sci 115(4):446-52 (2011)
    512011Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy.



    +-nlJ Pharmacol Sci 115(4):440-5 (2011)
    522011Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes.



    +-nlJ Pharmacol Sci 115(4):453-8 (2011)
    532004Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.



    +-nlJ Pharmacol Sci 94(3):221-32 (2004)
    542009Drug discovery for overcoming chronic kidney disease (CKD): prolyl-hydroxylase inhibitors to activate hypoxia-inducible factor (HIF) as a novel therapeutic approach in CKD.



    +-nlJ Pharmacol Sci 109(1):24-31 (2009)
    552003HIF hydroxylation and the mammalian oxygen-sensing pathway.



    +-nlJ Clin Invest 111(6):779-83 (2003)
    562010HIF-1: upstream and downstream of cancer metabolism.



    +-nlCurr Opin Genet Dev 20(1):51-6 (2010)
    572009When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.



    +-nlCancer Res 69(9):3723-6 (2009)
    582010PHD2 in tumour angiogenesis.



    +-nlBr J Cancer 103(1):1-5 (2010)
    592010Hypoxia inducible factors in cancer stem cells.



    +-nlBr J Cancer 102(5):789-95 (2010)
    602003Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.



    +-nlEur J Biochem 270(5):781-90 (2003)
    612003The subtle side to hypoxia inducible factor (HIFalpha) regulation.



    +-nlEur J Biochem 270(5):791-8 (2003)
    622004O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.



    +-nlJ Appl Physiol 96(3):1173-7; discussion 1170-2 (2004)
    632007Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.



    +-nlExp Physiol 92(6):988-91 (2007)
    642010Inflammation, HIF-1, and the epigenetics that follows.



    +-nlMediators Inflamm 2010(-):263914 (2010)
    652011Epigenetics: new questions on the response to hypoxia.



    +-nlInt J Mol Sci 12(7):4705-21 (2011)
    662010Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction.



    +-nlNucleic Acids Res 38(7):2332-45 (2010)
    672008The role of oxygen availability in embryonic development and stem cell function.



    +-nlNat Rev Mol Cell Biol 9(4):285-96 (2008)
    682010Hypoxic regulation of erythropoiesis and iron metabolism.



    +-nlAm J Physiol Renal Physiol 299(1):F1-13 (2010)



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