Data base (Medicine Biology Pharmacology) Bibliography of free accessible medical and biological reviews

Nr.	Year OPEN	Title	rate good	rate bad	no link	Citation
1	2003	"Medical Matrix": a directory of clinical, medical web sites.	+	-	nl	Clin Med Res 1(1):71-2 (2003)
2	2006	Scopus database: a review.	+	-	nl	Biomed Digit Libr 3(-):1 (2006)
3	2008	E-meducation.org: an open access medical education web portal.	+	-	nl	BMC Med Educ 8(-):6 (2008)
4	1998	Medical information on the Internet.	+	-	nl	Anesthesiology 89(5):1233-45 (1998)
5	2009	Analysis of complex disease association and linkage studies using the University of California Santa Cruz Genome Browser.	+	-	nl	Circ Cardiovasc Genet 2(2):199-204 (2009)
6	2004	PharmGKB: the pharmacogenetics and pharmacogenomics knowledge base.	+	-	nl	Pharmacogenomics J 4(1):1 (2004)
7	2005	Potential use of routine databases in health technology assessment.	+	-	nl	Health Technol Assess 9(20):1-92, iii-iv (2005)
8	1993	Colibri: a functional data base for the Escherichia coli genome.	+	-	nl	Microbiol Rev 57(3):623-54 (1993)
9	2009	Bioinformatics resources for the study of gene regulation in bacteria.	+	-	nl	J Bacteriol 191(1):23-31 (2009) Collado-Vides J
10	2005	Databases and software for the comparison of prokaryotic genomes.	+	-	nl	Microbiology 151(Pt 7):2125-32 (2005)
11	2005	Functional genomics databases on the web.	+	-	nl	Cell Microbiol 7(8):1053-9 (2005)
12	2007	National Institute of Allergy and Infectious Diseases bioinformatics resource centers: new assets for pathogen informatics.	+	-	nl	Infect Immun 75(7):3212-9 (2007)
13	2006	CED: a conformational epitope database.	+	-	nl	BMC Immunol 7(-):7 (2006)
14	1997	The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases.	+	-	nl	J Leukoc Biol 61(5):545-50 (1997)
15	2007	The European internet-based patient and research database for primary immunodeficiencies: results 2004-06.	+	-	nl	Clin Exp Immunol 147(2):306-12 (2007)
16	2008	UCSC genome browser tutorial.	+	-	nl	Genomics 92(2):75-84 (2008)
17	2009	Comparative analyses of plant transcription factor databases.	+	-	nl	Curr Genomics 10(1):10-7 (2009)
18	2009	JBrowse: a next-generation genome browser.	+	-	nl	Genome Res 19(9):1630-8 (2009)
19	2002	Time for a unified system of mutation description and reporting: a review of locus-specific mutation databases.	+	-	nl	Genome Res 12(5):680-8 (2002)
20	1998	WebWise: guide to the joint genome institute web site.	+	-	nl	Genome Res 8(9):864-9 (1998)
21	1998	WebWise: guide to the Washington University Center for Genetics in Medicine web site.	+	-	nl	Genome Res 8(7):686-9 (1998)
22	1998	WebWise: guide to the Institute of Molecular Biology Genome Sequencing Center-Jena web site.	+	-	nl	Genome Res 8(4):334-8 (1998)
23	2008	The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency.	+	-	nl	BMC Med Genet 9(-):20 (2008)
24	2005	Overview of BioCreAtIvE: critical assessment of information extraction for biology.	+	-	nl	BMC Bioinformatics 6 Suppl 1():S1 (2005) Hirschman L
25	2001	SWISS-PROT: connecting biomolecular knowledge via a protein database.	+	-	nl	Curr Issues Mol Biol 3(3):47-55 (2001)
26	2008	Open source GIS for HIV/AIDS management.	+	-	nl	Int J Health Geogr 7(-):53 (2008)
27	2006	Web GIS in practice IV: publishing your health maps and connecting to remote WMS sources using the Open Source UMN MapServer and DM Solutions MapLab.	+	-	nl	Int J Health Geogr 5(-):6 (2006)
28	2005	Web GIS in practice III: creating a simple interactive map of England's Strategic Health Authorities using Google Maps API, Google Earth KML, and MSN Virtual Earth Map Control.	+	-	nl	Int J Health Geogr 4(-):22 (2005)
29	2002	Searching the Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS) database improves systematic reviews.	+	-	nl	Int J Epidemiol 31(1):112-4 (2002)
30	2005	CareSearch: finding and evaluating Australia's missing palliative care literature.	+	-	nl	BMC Palliat Care 4(-):4 (2005)
31	2009	An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignancies.	+	-	nl	BMC Cancer 9(-):396 (2009)
32	2007	MutationView/KMcancerDB: a database for cancer gene mutations.	+	-	nl	Cancer Sci 98(3):259-67 (2007)
33	2006	Japanese single nucleotide polymorphism database for 267 possible drug-related genes.	+	-	nl	Cancer Sci 97(1):16-24 (2006)
34	2009	GEMS (Gene Expression MetaSignatures), a Web resource for querying meta-analysis of expression microarray datasets: 17beta-estradiol in MCF-7 cells.	+	-	nl	Cancer Res 69(1):23-6 (2009)
35	2002	The Mouse Tumor Biology Database: a public resource for cancer genetics and pathology of the mouse.	+	-	nl	Cancer Res 62(5):1235-40 (2002)
36	2007	Your database is obsolete: The promise of contextual bioinformatics.	+	-	nl	Bioinformation 1(9):356 (2007)
37	2007	Public databases and software for the pathway analysis of cancer genomes.	+	-	nl	Cancer Inform 3(-):379-97 (2007)
38	2002	Welcome, PIER, a new Physicians' Information and Education Resource.	+	-	nl	Ann Intern Med 136(7):553-4 (2002)
39	2007	The CASBAH: a searchable database of caspase substrates.	+	-	nl	Cell Death Differ 14(4):641-50 (2007)
40	1998	A practical guide to orient yourself in the labyrinth of genome databases.	+	-	nl	Hum Mol Genet 7(10):1641-8 (1998)
41	2009	The Israeli National Genetic Database.	+	-	nl	Isr Med Assoc J 11(6):373-5 (2009)
42	2005	Observational research databases in renal disease.	+	-	nl	J Am Soc Nephrol 16(12):3477-84 (2005)
43	2001	Endocrinology resources on the internet.	+	-	nl	J Clin Endocrinol Metab 86(7):2942-5 (2001)
44	2000	Pituitary tumor registry: a novel clinical resource.	+	-	nl	J Clin Endocrinol Metab 85(1):168-74 (2000)
45	2008	General mutation databases: analysis and review.	+	-	nl	J Med Genet 45(2):65-70 (2008)
46	1998	Mutation databases on the Web.	+	-	nl	J Med Genet 35(7):529-33 (1998)
47	2005	Trial Registration at ClinicalTrials.gov between May and October 2005.	+	-	nl	N Engl J Med 353(26):2779-87 (2005) Zarin DA
48	2006	Translating knowledge of the human genome into clinical practice in nephrology dialysis and transplantation: the renal genome network (ReGeNet).	+	-	nl	Nephrol Dial Transplant 21(10):2681-3 (2006) Brenchley PE
49	2004	Clinical guidelines online: do they improve compliance?	+	-	nl	Postgrad Med J 80(945):415-9 (2004)
50	2009	TFCat: the curated catalog of mouse and human transcription factors.	+	-	nl	Genome Biol 10(3):R29 (2009)
51	2002	Tools and resources for identifying protein families, domains and motifs.	+	-	nl	Genome Biol 3(1):REVIEWS2001 (2002)
52	2001	Microarray gene expression database: progress towards an international repository of gene expression data.	+	-	nl	Genome Biol 2(5):REPORTS4011 (2001)
53	2004	The Ensembl core software libraries.	+	-	nl	Genome Res 14(5):929-33 (2004)
54	2004	An overview of Ensembl.	+	-	nl	Genome Res 14(5):925-8 (2004)
55	1999	A survey of web resources for basic cancer genetics research.	+	-	nl	Genome Res 9(5):397-408 (1999)
56	2008	Human Proteinpedia as a resource for clinical proteomics.	+	-	nl	Mol Cell Proteomics 7(10):2038-47 (2008)
57	2010	The Gene Wiki: community intelligence applied to human gene annotation.	+	-	nl	Nucleic Acids Res 38(Database issue):D633-9 (2010)
58	2009	ToppGene Suite for gene list enrichment analysis and candidate gene prioritization.	+	-	nl	Nucleic Acids Res 37(Web Server issue):W305-11 (2009)
59	2009	miR2Disease: a manually curated database for microRNA deregulation in human disease.	+	-	nl	Nucleic Acids Res 37(Database issue):D98-104 (2009)
60	2009	PTM-Switchboard--a database of posttranslational modifications of transcription factors, the mediating enzymes and target genes.	+	-	nl	Nucleic Acids Res 37(Database issue):D66-71 (2009)
61	2009	ExplorEnz: the primary source of the IUBMB enzyme list.	+	-	nl	Nucleic Acids Res 37(Database issue):D593-7 (2009)
62	2008	Microarray retriever: a web-based tool for searching and large scale retrieval of public microarray data.	+	-	nl	Nucleic Acids Res 36(Web Server issue):W327-31 (2008)
63	2008	The Genomes On Line Database (GOLD) in 2007: status of genomic and metagenomic projects and their associated metadata.	+	-	nl	Nucleic Acids Res 36(Database issue):D475-9 (2008)
64	2008	The Molecule Pages database.	+	-	nl	Nucleic Acids Res 36(Database issue):D700-6 (2008)
65	2008	CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.	+	-	nl	Nucleic Acids Res 36(Database issue):D892-900 (2008)
66	2007	Graph-based identification of cancer signaling pathways from published gene expression signatures using PubLiME.	+	-	nl	Nucleic Acids Res 35(7):2343-55 (2007)
67	2007	CellCircuits: a database of protein network models.	+	-	nl	Nucleic Acids Res 35(Database issue):D538-45 (2007)
68	2007	WormBook: the online review of Caenorhabditis elegans biology.	+	-	nl	Nucleic Acids Res 35(Database issue):D472-5 (2007)
69	2006	MetaCyc: a multiorganism database of metabolic pathways and enzymes.	+	-	nl	Nucleic Acids Res 34(Database issue):D511-6 (2006)
70	2005	GPS: a comprehensive www server for phosphorylation sites prediction.	+	-	nl	Nucleic Acids Res 33(Web Server issue):W184-7 (2005)
71	2004	PeerGAD: a peer-review-based and community-centric web application for viewing and annotating prokaryotic genome sequences.	+	-	nl	Nucleic Acids Res 32(10):3124-35 (2004)
72	2004	RTCGD: retroviral tagged cancer gene database.	+	-	nl	Nucleic Acids Res 32(Database issue):D523-7 (2004)
73	2004	GeneDB: a resource for prokaryotic and eukaryotic organisms.	+	-	nl	Nucleic Acids Res 32(Database issue):D339-43 (2004)
74	2003	The MetaFMF website: a high quality tool for meta-analysis of FMF.	+	-	nl	Nucleic Acids Res 31(1):286-90 (2003) Pugnere D
75	2003	INFEVERS: the Registry for FMF and hereditary inflammatory disorders mutations.	+	-	nl	Nucleic Acids Res 31(1):282-5 (2003)
76	2002	The MetaCyc Database.	+	-	nl	Nucleic Acids Res 30(1):59-61 (2002)
77	2000	HGBASE: a database of SNPs and other variations in and around human genes.	+	-	nl	Nucleic Acids Res 28(1):356-60 (2000)
78	1999	A comprehensive comparison of multiple sequence alignment programs.	+	-	nl	Nucleic Acids Res 27(13):2682-90 (1999)
79	1997	EcoCyc: Enyclopedia of Escherichia coli Genes and Metabolism.	+	-	nl	Nucleic Acids Res 25(1):43-51 (1997)
80	1996	EcoCyc: an encyclopedia of Escherichia coli genes and metabolism.	+	-	nl	Nucleic Acids Res 24(1):32-9 (1996)
81	2002	Gene homology resources on the World Wide Web.	+	-	nl	Physiol Genomics 11(3):165-77 (2002)
82	2008	TranscriptomeBrowser: a powerful and flexible toolbox to explore productively the transcriptional landscape of the Gene Expression Omnibus database.	+	-	nl	PLoS One 3(12):e4001 (2008)
83	2004	Management of fever in neutropenic patients with different risks of complications.	+	-	nl	Clin Infect Dis 39 Suppl 1(-):S32-7 (2004)
84	1995	Knockouts. Targeting the mouse genome: a compendium of knockouts (Part I)	+	-	nl	Curr Biol 5(6):625-34 (1995)
85	2002	MINT: a Molecular INTeraction database.	+	-	nl	FEBS Lett 513(1):135-40 (2002)
86	2001	E-BioSci.	+	-	nl	FEBS Lett 498(2-3):123 (2001)
87	1998	Human and mouse proteomic databases: novel resources in the protein universe.	+	-	nl	FEBS Lett 430(1-2):64-72 (1998)
88	1996	Human 2-D PAGE databases for proteome analysis in health and disease: http://biobase.dk/cgi-bin/celis.	+	-	nl	FEBS Lett 398(2-3):129-34 (1996)
89	1989	Comprehensive, human cellular protein databases and their implication for the study of genome organization and function.	+	-	nl	FEBS Lett 244(2):247-54 (1989)
90	2005	Large macromolecular complexes in the Protein Data Bank: a status report.	+	-	nl	Structure 13(3):381-8 (2005)
91	1998	CAMPASS: a database of structurally aligned protein superfamilies.	+	-	nl	Structure 6(9):1087-94 (1998)
92	2007	Informatics in radiology: RadiologyWiki.org: the free radiology resource that anyone can edit.	+	-	nl	Radiographics 27(4):1193-200 (2007)
93	2007	Radiology education in 2005: world wide web practice patterns, perceptions, and preferences of radiologists.	+	-	nl	Radiographics 27(2):563-71 (2007) Rowell MR
94	2006	RadLex: a new method for indexing online educational materials.	+	-	nl	Radiographics 26(6):1595-7 (2006)
95	2005	infoRAD 2005: your best resource for informatics education.	+	-	nl	Radiographics 25(5):1405-6 (2005)
96	1996	MoSearch: a radiologist-friendly tool for finding-based diagnostic report and image retrieval.	+	-	nl	Radiographics 16(4):923-33 (1996)
97	1995	CHORUS: a computer-based radiology handbook for international collaboration via the World Wide Web.	+	-	nl	Radiographics 15(4):963-70 (1995)
98	2009	The Human Ageing Genomic Resources: online databases and tools for biogerontologists.	+	-	nl	Aging Cell 8(1):65-72 (2009)
99	2008	A searchable database of genetic evidence for psychiatric disorders.	+	-	nl	Am J Med Genet B Neuropsychiatr Genet 147B(6):671-5 (2008)
100	2005	The CORRONA database.	+	-	nl	Ann Rheum Dis 64 Suppl 4(-):iv37-41 (2005)
101	2003	Databases in the biological sciences. A user's guide to the current copyright landscape.	+	-	nl	Plant Physiol 132(3):1131-4 (2003)
102	2005	Biological databases for plant research.	+	-	nl	Plant Physiol 138(1):1-3 (2005)
103	2005	The maize genetics and genomics database. The community resource for access to diverse maize data.	+	-	nl	Plant Physiol 138(1):55-8 (2005) Lawrence CJ
104	2006	Natural products: sources and databases.	+	-	nl	Nat Prod Rep 23(3):347-56 (2006)
105	2010	Unmet challenges of structural genomics.	+	-	nl	Curr Opin Struct Biol 20(5):587-97 (2010)
106	2007	Visualization software for molecular assemblies.	+	-	nl	Curr Opin Struct Biol 17(5):587-95 (2007)
107	2009	Is protein classification necessary? Toward alternative approaches to function annotation.	+	-	nl	Curr Opin Struct Biol 19(3):363-8 (2009)
108	2011	FARO server: Meta-analysis of gene expression by matching gene expression signatures to a compendium of public gene expression data.	+	-	nl	BMC Res Notes 4(-):181 (2011)
109	2010	Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase.	+	-	nl	BMC Syst Biol 4(-):137 (2010)
110	2008	Biomolecular network querying: a promising approach in systems biology.	+	-	nl	BMC Syst Biol 2(-):5 (2008)
111	2010	DeathBase: a database on structure, evolution and function of proteins involved in apoptosis and other forms of cell death.	+	-	nl	Cell Death Differ 17(5):735-6 (2010)
112	2003	The apoptosis database.	+	-	nl	Cell Death Differ 10(6):621-33 (2003)
113	2011	Advancing science through mining libraries, ontologies, and communities.	+	-	nl	J Biol Chem 286(27):23659-66 (2011)
114	2011	Discovering the targets of drugs via computational systems biology.	+	-	nl	J Biol Chem 286(27):23653-8 (2011)
115	2007	Paratope and epitope mapping of the antithrombotic antibody 6B4 in complex with platelet glycoprotein Ibalpha.	+	-	nl	J Biol Chem 282(32):23517-24 (2007)
116	2008	Why and how to use the photographic atlases of the American Registry of Pathology.	+	-	nl	Medscape J Med 10(10):235 (2008)
117	2005	Towards writing the encyclopedia of life: an introduction to DNA barcoding.	+	-	nl	Philos Trans R Soc Lond B Biol Sci 360(1462):1805-11 (2005)
118	2009	Update of the LIPID MAPS comprehensive classification system for lipids.	+	-	nl	J Lipid Res 50 Suppl(-):S9-14 (2009)
119	2008	National and international registries of rare bleeding disorders.	+	-	nl	Blood Transfus 6 Suppl 2(-):s45-8 (2008)
120	2004	Research applications of the Cambridge Structural Database (CSD).	+	-	nl	Chem Soc Rev 33(8):463-75 (2004)
121	2010	Bioinformatics and molecular modeling in glycobiology.	+	-	nl	Cell Mol Life Sci 67(16):2749-72 (2010)
122	2010	From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.	+	-	nl	Cell Mol Life Sci 67(7):1049-64 (2010)
123	2009	Genome sequence data: management, storage, and visualization.	+	-	nl	Biotechniques 46(5):333-4, 336 (2009)
124	2006	WebMD, Medscape, eMedicine, and the relevance of a medical encyclopedia in 2006.	+	-	nl	MedGenMed 8(1):32 (2006)
125	2011	The BCG world atlas: a new, open-access resource for clinicians and researchers.	+	-	nl	Expert Rev Anti Infect Ther 9(8):559-61 (2011)
126	2008	The ISS Sensitizing Agents Data Bank (BDS).	+	-	nl	Ann Ist Super Sanita 44(1):64-74 (2008)
127	2008	A new database for food safety: EDID (Endocrine disrupting chemicals - Diet Interaction Database).	+	-	nl	Ann Ist Super Sanita 44(1):57-63 (2008)
128	2008	A novel approach: chemical relational databases, and the role of the ISSCAN database on assessing chemical carcinogenicity.	+	-	nl	Ann Ist Super Sanita 44(1):48-56 (2008)
129	2008	The ISS Carcinogens Data Bank (BDC).	+	-	nl	Ann Ist Super Sanita 44(1):31-42 (2008)
130	2008	The ISS National Inventory of Chemical Substances (INSC).	+	-	nl	Ann Ist Super Sanita 44(1):16-26 (2008)
131	2003	A review of new databases and associated web tools.	+	-	nl	Brief Bioinform 4(1):91-8 (2003)
132	2008	Protein structure databases with new web services for structural biology and biomedical research.	+	-	nl	Brief Bioinform 9(4):276-85 (2008)
133	2006	Advances in the Exon-Intron Database (EID).	+	-	nl	Brief Bioinform 7(2):178-85 (2006)
134	2010	Using database research to affect the science and art of medicine.	+	-	nl	Anesthesiology 113(2):268-70 (2010)
135	2010	T3SEdb: data warehousing of virulence effectors secreted by the bacterial Type III Secretion System.	+	-	nl	BMC Bioinformatics 11 Suppl 7(-):S4 (2010)
136	2004	VKCDB: voltage-gated potassium channel database.	+	-	nl	BMC Bioinformatics 5(-):3 (2004)
137	2007	PADB: published association database.	+	-	nl	BMC Bioinformatics 8(-):348 (2007)
138	2007	PedGenie: meta genetic association testing in mixed family and case-control designs.	+	-	nl	BMC Bioinformatics 8(-):448 (2007)
139	2007	Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base.	+	-	nl	BMC Bioinformatics 8(-):177 (2007)
140	2007	sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database.	+	-	nl	BMC Bioinformatics 8(-):178 (2007)
141	2008	Chromhome: a rich internet application for accessing comparative chromosome homology maps.	+	-	nl	BMC Bioinformatics 9(-):168 (2008)
142	2008	ArrayWiki: an enabling technology for sharing public microarray data repositories and meta-analyses.	+	-	nl	BMC Bioinformatics 9 Suppl 6(-):S18 (2008)
143	2006	The Autoimmune Disease Database: a dynamically compiled literature-derived database.	+	-	nl	BMC Bioinformatics 7(-):325 (2006)
144	2008	Catmap: case-control and TDT meta-analysis package.	+	-	nl	BMC Bioinformatics 9(-):130 (2008)
145	2009	The European internet-based patient and research database for primary immunodeficiencies: results 2006-2008.	+	-	nl	Clin Exp Immunol 157 Suppl 1(-):3-11 (2009)
146	2006	Roadmap or roadkill: a pharmacologist's analysis of the NIH Molecular Libraries Initiative.	+	-	nl	Mol Interv 6(5):240-3 (2006)
147	2002	Evaluation of sequence motifs found in scaffold/matrix-attached regions (S/MARs).	+	-	nl	Nucleic Acids Res 30(15):3433-42 (2002)
148	2011	Bovine Genome Database: integrated tools for genome annotation and discovery.	+	-	nl	Nucleic Acids Res 39(Database issue):D830-4 (2011)
149	2011	Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting.	+	-	nl	Nucleic Acids Res 39(12):e82 (2011)
150	2011	NCBI Epigenomics: a new public resource for exploring epigenomic data sets.	+	-	nl	Nucleic Acids Res 39(Database issue):D908-12 (2011)
151	2011	Towards BioDBcore: a community-defined information specification for biological databases.	+	-	nl	Nucleic Acids Res 39(Database issue):D7-10 (2011)
152	2011	NCBI GEO: archive for functional genomics data sets--10 years on.	+	-	nl	Nucleic Acids Res 39(Database issue):D1005-10 (2011)
153	2011	OMA 2011: orthology inference among 1000 complete genomes.	+	-	nl	Nucleic Acids Res 39(Database issue):D289-94 (2011)
154	2010	MAGIA, a web-based tool for miRNA and Genes Integrated Analysis.	+	-	nl	Nucleic Acids Res 38(Web Server issue):W352-9 (2010)
155	2010	WIWS: a protein structure bioinformatics Web service collection.	+	-	nl	Nucleic Acids Res 38(Web Server issue):W719-23 (2010)
156	2010	ProBiS: a web server for detection of structurally similar protein binding sites.	+	-	nl	Nucleic Acids Res 38(Web Server issue):W436-40 (2010)
157	2010	MARQ: an online tool to mine GEO for experiments with similar or opposite gene expression signatures.	+	-	nl	Nucleic Acids Res 38(Web Server issue):W228-32 (2010)
158	2004	siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.	+	-	nl	Nucleic Acids Res 32(Web Server issue):W124-9 (2004)
159	2010	The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants.	+	-	nl	Nucleic Acids Res 38(6):1767-71 (2010)
160	2007	eTBLAST: a web server to identify expert reviewers, appropriate journals and similar publications.	+	-	nl	Nucleic Acids Res 35(Web Server issue):W12-5 (2007)

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All data shown were primarily retrieved from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.