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  • ALK5
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  • SM16
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    12009TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.



    		+-nlEMBO J 28(2):88-98 (2009) Liu IM
    22005Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling.



    		+-nlPhysiol Genomics 21(3):396-403 (2005) Karlsson G
    32009Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.



    		+-nlAm J Pathol 174(2):380-9 (2009) Thomas M
    42008Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.



    		+-nlAm J Physiol Lung Cell Mol Physiol 295(1):L123-33 (2008) Lu Q
    52006Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development.



    		+-nlLab Invest 86(2):116-29 (2006) Seki T
    62006TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5.



    		+-nlStem Cells 24(11):2420-7 (2006) Mallet C
    72009TGF-beta inhibits vascular sprouting through TGF-beta type I receptor in the mouse embryonic aorta.



    		+-nlTohoku J Exp Med 218(1):63-71 (2009) Ito C
    82005Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.



    		+-nlAm J Pathol 167(6):1699-711 (2005) Chen Y
    91998Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar.



    		+-nlAm J Pathol 152(2):485-93 (1998)
    102006Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.



    		+-nlArthritis Rheum 54(4):1309-16 (2006) Chen Y
    111994TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.



    		+-nlJ Cell Biol 127(6 Pt 2):2021-36 (1994)
    121999TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.



    		+-nlJ Cell Sci 112 ( Pt 24)(-):4557-68 (1999)
    132008Signaling via the Tgf-beta type I receptor Alk5 in heart development.



    		+-nlDev Biol 322(1):208-18 (2008) Sridurongrit S
    142007Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation.



    		+-nlDev Biol 304(1):420-32 (2007) Mercado-Pimentel ME
    152006Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.



    		+-nlDev Biol 296(2):298-314 (2006) Dudas M
    162006Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells.



    		+-nlDev Dyn 235(1):82-93 (2006) Compton LA
    172006Transforming growth factor-beta stimulates epithelial-mesenchymal transformation in the proepicardium.



    		+-nlDev Dyn 235(1):50-9 (2006) Olivey HE
    182008Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion.



    		+-nlMech Dev 125(9-10):874-82 (2008) Li WY
    192006Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects.



    		+-nlBMC Dev Biol 6():51 (2006) Wang J
    202000Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.



    		+-nlInt J Dev Biol 44(3):253-65 (2000)
    212008Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype.



    		+-nlCancer Res 68(6):1656-66 (2008) Bharathy S
    222003Disease-associated mutations in conserved residues of ALK-1 kinase domain.



    		+-nlEur J Hum Genet 11(4):279-87 (2003) Abdalla SA
    232005Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.



    		+-nlAm J Respir Crit Care Med 171(8):889-98 (2005) Bonniaud P
    242007SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.



    		+-nlAntimicrob Agents Chemother 51(8):2905-10 (2007) Waghabi MC
    252008SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.



    		+-nlArterioscler Thromb Vasc Biol 28(4):665-71 (2008) Fu K
    262004Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.



    		+-nlArthritis Rheum 50(12):4008-21 (2004) Mori Y
    272008Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.



    		+-nlBlood 112(8):3434-43 (2008) Zhou L
    282005Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.



    		+-nlBr J Pharmacol 145(2):166-77 (2005) de Gouville AC
    292007A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.



    		+-nlCancer Res 67(5):2351-9 (2007) Suzuki E
    302003SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.



    		+-nlCancer Res 63(22):7791-8 (2003) Matsuyama S
    312007Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats.



    		+-nlClin Cancer Res 13(10):3087-99 (2007) Laping NJ
    322008TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.



    		+-nlJ Cell Biol 182(4):655-62 (2008) Kowanetz M
    332006Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.



    		+-nlJ Invest Dermatol 126(8):1733-44 (2006) Ishida W
    342005Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis.



    		+-nlJ Pharmacol Exp Ther 313(3):943-51 (2005) Grygielko ET
    352004SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.



    		+-nlMol Pharmacol 65(3):744-52 (2004) DaCosta Byfield S
    362002SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.



    		+-nlMol Pharmacol 62(1):65-74 (2002)
    372002Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.



    		+-nlMol Pharmacol 62(1):58-64 (2002)
    382008Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium.



    		+-nlMol Vis 14():2272-81 (2008) Sumioka T
    392006Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis.



    		+-nlEMBO Rep 7(8):831-7 (2006) Andersson O
    402004Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5.



    		+-nlMol Endocrinol 18(3):653-65 (2004) Mazerbourg S

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