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PDE4
LE WE PMID CA
PDE44082PDE4

CAMP

COPD

Ibudilast

PDE phosphodiesterase

PDE3

PDE4

Roflumilast ttPDE4

Theophylline

2008  
1
PDE4 inhibitors: current status.
[18660825] Br J Pharmacol 155(3): 308-15 (2008)
2003  
2
Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.
[12493749] J Biol Chem 278(8): 5493-6 (2003)
2009  
3
Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.
[19508401] Br J Pharmacol 157(6): 892-906 (2009)
2003  
4
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
[12444918] Biochem J 370(Pt 1): 1-18 (2003)
2010  
5
The role of the phosphodiesterase-4 inhibitor, roflumilast, in chronic obstructive pulmonary disease.
[20150838] Pol Arch Med Wewn 120(1-2): 9-10 (2010)
2008  
6
Phosphodiesterase 4 inhibitors in chronic obstructive pulmonary disease: a new approach to oral treatment.
[18341675] Br J Clin Pharmacol 65(6): 803-10 (2008)
2010  
7
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.
[20689641] Drug Des Devel Ther 4(-): 147-58 (2010)

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All Medline data shown were primarily retrieved from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.


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