Epoxyeicosatrienoic acid EET

Arachidonic acid cytochrome P450 epoxygenase pathway.
[18952572] J Lipid Res 50 Suppl(-): S52-6 (2009)

Red blood cells (RBCs), epoxyeicosatrienoic acids (EETs) and adenosine triphosphate (ATP).
[20631410] Pharmacol Rep 62(3): 468-74 (2010)

Purinoceptors in renal microvessels: adenosine-activated and cytochrome P450 monooxygenase-derived arachidonate metabolites.
[16415499] Pharmacol Rep 57 Suppl(-): 191-5 (2005)

Epoxygenases and peroxisome proliferator-activated receptors in mammalian vascular biology.
[17872966] Exp Physiol 93(1): 148-54 (2008)

Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation.
[19891972] J Mol Cell Cardiol 48(2): 331-41 (2010)

TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure.
[19617407] Am J Physiol Heart Circ Physiol 297(3): H1096-102 (2009)

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
[18378772] J Cell Biol 181(1): 143-55 (2008)

High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.
[17962608] Am J Respir Cell Mol Biol 38(4): 386-92 (2008)

Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.
[18682435] Cardiovasc Res 80(3): 445-52 (2008)

Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.
[17008604] Circ Res 99(9): 988-95 (2006)

EDHF redux: EETs, TRPV4, and Ca2+ sparks.
[16339490] Circ Res 97(12): 1209-10 (2005)

IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.
[18826956] J Biol Chem 283(46): 31284-8 (2008)

Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid.
[22365750] Atherosclerosis 222(1): 92-8 (2012)

IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
[18443356] J Gen Physiol 131(5): i2 (2008)

Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation.
[18836067] J Pharmacol Exp Ther 328(1): 231-9 (2009)

Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury.
[20163540] Microcirculation 17(2): 137-46 (2010)

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.
[19666518] Proc Natl Acad Sci U S A 106(33): 14034-9 (2009)

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.
[14691263] Proc Natl Acad Sci U S A 101(1): 396-401 (2004)

Ca2+ channels and pulmonary endothelial permeability: insights from study of intact lung and chronic pulmonary hypertension.
[17085430] Microcirculation 13(8): 725-39 (2006)

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels.
[12879072] Nature 424(6947): 434-8 (2003)

Epoxyeicosatrienoic acid analogs and vascular function.
[20158473] Curr Med Chem 17(12): 1181-90 (2010)

Targeting epoxides for organ damage in hypertension.
[20531214] J Cardiovasc Pharmacol 56(4): 329-35 (2010)

Soluble epoxide hydrolase in atherosclerosis.
[20425256] Curr Atheroscler Rep 12(3): 174-83 (2010)

Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).
[17164131] Prostaglandins Other Lipid Mediat 82(1-4): 42-9 (2007)

Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury.
[17164132] Prostaglandins Other Lipid Mediat 82(1-4): 50-9 (2007)

Epoxyeicosanoid signaling in CNS function and disease.
[19545642] Prostaglandins Other Lipid Mediat 91(3-4): 68-84 (2010)

Cytochrome P450-derived eicosanoids: the neglected pathway in cancer.
[20941528] Cancer Metastasis Rev 29(4): 723-35 (2010)

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