LE WE PMID CA
Endothelin806Endothelin

Ambrisentan

Blood vessels (Physiology)

Bosentan

BQ123 ttEndothelinETA

BQ788 ttEndothelinETB

Clazosentan

CNS (Subarachnoid hemorrhage)

Cold (Physiology)

Eisenmenger s syndrome

Endothelin converting enzyme

Endothelin

Enrasentan

Epithelio mesenchymal transition

Heart (Physiology)

HIF1alpha und HIF1 (BASKET)

Kidney (Chronic renal failure)

Kidney (Nerves afferent)

Kidney (Pressure natriuresis)

Kidney (Progression of renal disease)

Liver (Anatomy)

Lung (Fibrosis)

Macitentan

Melanocyte

NADPH oxidase

Neoplasia (Tumor biology and immunology)

Nicotine

Pelvis (Kidney)

Prostate (Neoplasia)

Pulmonary hypertension

Skin (Neoplasia Melanoma)

Substance P

TRPV1

ZD4054 ttET1RA

1994  
1
Endothelins. Biochemistry and pathophysiologic actions.
[8024144] Anesthesiology 80(4): 892-905 (1994)
2005  
2
Endothelin antagonism in pulmonary hypertension, heart failure, and beyond.
[15894792] Heart 91(6): 825-31 (2005)
2006  
3
Ambrisentan, a non-peptide endothelin receptor antagonist.
[16939634] Cardiovasc Drug Rev 24(1): 63-76 (2006)
2005  
4
CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme.
[16614731] Cardiovasc Drug Rev 23(4): 317-30 (2005)
2003  
5
Enrasentan, an antagonist of endothelin receptors.
[12595914] Cardiovasc Drug Rev 21(1): 1-16 (2003)
2002  
6
Endothelin antagonism with bosentan: current status and future perspectives.
[12070530] Cardiovasc Drug Rev 20(1): 1-18 (2002)
2010  
7
Endothelin receptor antagonists for pulmonary arterial hypertension: an overview.
[20406243] Cardiovasc Ther 28(5): e65-71 (2010)
2007  
8
The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.
[17617392] Cardiovasc Res 76(1): 8-18 (2007)
2004  
9
The endothelin system in pulmonary arterial hypertension.
[14736539] Cardiovasc Res 61(2): 227-37 (2004)
2001  
10
Endothelin as a natriuretic hormone: the case for a paracrine action mediated by nitric oxide.
[11476738] Cardiovasc Res 51(3): 481-8 (2001)
1997  
11
Endothelin: from molecule to man.
[9241091] Br J Clin Pharmacol 44(1): 9-20 (1997)
2002  
12
International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
[12037137] Pharmacol Rev 54(2): 219-26 (2002)
1996  
13
Molecular pharmacology and pathophysiological significance of endothelin.
[9015736] Jpn J Pharmacol 72(4): 261-90 (1996)
1991  
14
2006  
15
Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drug.
[16740981] Exp Biol Med (Maywood) 231(6): 653-95 (2006)
2008  
16
Role of endothelin-1 in clinical hypertension: 20 years on.
[18678788] Hypertension 52(3): 452-9 (2008)
1991  
17
Endothelins: a family of regulatory peptides. State-of-the-art lecture.
[1646169] Hypertension 17(6 Pt 2): 856-63 (1991)
1996  
18
Endothelin in renal pathophysiology: from experimental to therapeutic application.
[8943463] Kidney Int 50(6): 1827-33 (1996)
1993  
19
Renal actions of endothelin.
[8377389] Kidney Int 44(2): 451-63 (1993)
2010  
20
Up-regulation of endothelin receptors induced by cigarette smoke--involvement of MAPK in vascular and airway hyper-reactivity.
[21057729] ScientificWorldJournal 10(-): 2157-66 (2010)
2008  
21
Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial.
[18688013] Stroke 39(11): 3015-21 (2008)
2008  
22
Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases.
[18551924] Rev Port Cardiol 27(3): 385-408 (2008)
2009  
23
Drug discovery for overcoming chronic kidney disease (CKD): the endothelin ET B receptor/nitric oxide system functions as a protective factor in CKD.
[19151534] J Pharmacol Sci 109(1): 7-13 (2009)
2008  
24
The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?
[17965745] Br J Pharmacol 153(6): 1105-19 (2008)
2011  
25
2008  
26
2009  
27
Endothelin receptor antagonist therapy in congenital heart disease with shunt-associated pulmonary arterial hypertension: a qualitative systematic review.
[19279988] Can J Cardiol 25(3): e63-8 (2009)
2010  
28
Role of endothelin receptor A and NADPH oxidase in vascular abnormalities.
[20859547] Vasc Health Risk Manag 6(-): 787-94 (2010)
2010  
29
Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic.
[19717811] Am J Respir Cell Mol Biol 42(1): 16-20 (2010)
2007  
30
Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis.
[17575081] Am J Respir Cell Mol Biol 37(1): 1-2 (2007)
2010  
31
Endothelin, hypertension and chronic kidney disease: new insights.
[20051851] Curr Opin Nephrol Hypertens 19(2): 134-9 (2010)
2007  
32
Endothelins and hypoxia-inducible factor in cancer.
[17639040] Endocr Relat Cancer 14(2): 233-44 (2007)
2009  
33
Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance.
[19858408] Hypertension 54(6): 1298-305 (2009)
2012  
34
Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction.
[22442497] J Mol Cell Biol 4(2): 97-107 (2012)
2008  
35
ZD4054: a specific endothelin A receptor antagonist with promising activity in metastatic castration-resistant prostate cancer.
[18616419] Expert Opin Investig Drugs 17(8): 1237-45 (2008)
2007  
36
Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease.
[17002597] Annu Rev Pharmacol Toxicol 47(-): 731-59 (2007)
2010  
37
Roles of endothelin signaling in melanocyte development and melanoma.
[20128875] Pigment Cell Melanoma Res 23(2): 160-70 (2010)
2010  
38
Endothelin-1 as a neuropeptide: neurotransmitter or neurovascular effects?
[19847673] J Cell Commun Signal 4(1): 51-62 (2010)
2010  
39
Endothelin receptors: what's new and what do we need to know?
[19907001] Am J Physiol Regul Integr Comp Physiol 298(2): R254-60 (2010)
PMC   
40
Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
[24498134] PLoS One 9(1):e87548 (2014)
PMC   
41
Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow.
[22961736] J Cell Biochem 114(2):435-47 (2013)
PMC   
42
Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension.
[22688668] J Cell Physiol 228(2):322-9 (2013)

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