LE WE PMID CA
ALK596ALK5

ALK5

SD208

SM16

2009  
1
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.
[19096363] EMBO J 28(2): 88-98 (2009)
2005  
2
Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling.
[15769904] Physiol Genomics 21(3): 396-403 (2005)
2009  
3
Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.
[19116361] Am J Pathol 174(2): 380-9 (2009)
2008  
4
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
[18456797] Am J Physiol Lung Cell Mol Physiol 295(1): L123-33 (2008)
2006  
5
Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development.
[16344855] Lab Invest 86(2): 116-29 (2006)
2006  
6
TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5.
[17071858] Stem Cells 24(11): 2420-7 (2006)
2009  
7
TGF-beta inhibits vascular sprouting through TGF-beta type I receptor in the mouse embryonic aorta.
[19398875] Tohoku J Exp Med 218(1): 63-71 (2009)
2005  
8
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
[16314481] Am J Pathol 167(6): 1699-711 (2005)
1998  
9
Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar.
[9466575] Am J Pathol 152(2): 485-93 (1998)
2006  
10
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.
[16575856] Arthritis Rheum 54(4): 1309-16 (2006)
1994  
11
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.
[7806579] J Cell Biol 127(6 Pt 2): 2021-36 (1994)
1999  
12
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
[10574705] J Cell Sci 112 ( Pt 24)(-): 4557-68 (1999)
2008  
13
Signaling via the Tgf-beta type I receptor Alk5 in heart development.
[18718461] Dev Biol 322(1): 208-18 (2008)
2007  
14
Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation.
[17250821] Dev Biol 304(1): 420-32 (2007)
2006  
15
Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion.
[16806156] Dev Biol 296(2): 298-314 (2006)
2006  
16
Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells.
[16258965] Dev Dyn 235(1): 82-93 (2006)
2006  
17
Transforming growth factor-beta stimulates epithelial-mesenchymal transformation in the proepicardium.
[16245329] Dev Dyn 235(1): 50-9 (2006)
2008  
18
Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion.
[18586087] Mech Dev 125(9-10): 874-82 (2008)
2006  
19
Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects.
[17078885] BMC Dev Biol 6(): 51 (2006)
2000  
20
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.
[10853822] Int J Dev Biol 44(3): 253-65 (2000)
2008  
21
Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype.
[18339844] Cancer Res 68(6): 1656-66 (2008)
2003  
22
Disease-associated mutations in conserved residues of ALK-1 kinase domain.
[12700602] Eur J Hum Genet 11(4): 279-87 (2003)
2005  
23
Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.
[15563636] Am J Respir Crit Care Med 171(8): 889-98 (2005)
2007  
24
SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion.
[17526757] Antimicrob Agents Chemother 51(8): 2905-10 (2007)
2008  
25
SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model.
[18202322] Arterioscler Thromb Vasc Biol 28(4): 665-71 (2008)
2004  
26
Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.
[15593186] Arthritis Rheum 50(12): 4008-21 (2004)
2008  
27
Inhibition of the TGF-beta receptor I kinase promotes hematopoiesis in MDS.
[18474728] Blood 112(8): 3434-43 (2008)
2005  
28
Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis.
[15723089] Br J Pharmacol 145(2): 166-77 (2005)
2007  
29
A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection.
[17332368] Cancer Res 67(5): 2351-9 (2007)
2003  
30
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
[14633705] Cancer Res 63(22): 7791-8 (2003)
2007  
31
Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats.
[17505012] Clin Cancer Res 13(10): 3087-99 (2007)
2008  
32
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.
[18725536] J Cell Biol 182(4): 655-62 (2008)
2006  
33
Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo.
[16741519] J Invest Dermatol 126(8): 1733-44 (2006)
2005  
34
Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis.
[15769863] J Pharmacol Exp Ther 313(3): 943-51 (2005)
2004  
35
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
[14978253] Mol Pharmacol 65(3): 744-52 (2004)
2002  
36
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
[12065756] Mol Pharmacol 62(1): 65-74 (2002)
2002  
37
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
[12065755] Mol Pharmacol 62(1): 58-64 (2002)
2008  
38
Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium.
[19081766] Mol Vis 14(): 2272-81 (2008)
2006  
39
Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis.
[16845371] EMBO Rep 7(8): 831-7 (2006)
2004  
40
Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5.
[14684852] Mol Endocrinol 18(3): 653-65 (2004)

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